Low dose of ethanol induces conditioned place preference in rats after repeated exposures to ethanol or saline injections.

نویسندگان

  • P Bienkowski
  • P Kuca
  • J Piasecki
  • W Kostowski
چکیده

Using the place conditioning paradigm (biased design), we have shown that five conditioning sessions with ethanol (0.5 or 1.0 g/kg i.p.) did not result in place conditioning response. In contrast, rats that received 20 injections of ethanol (0.5 g/kg) or saline, before the conditioning procedure, showed significant place preference to the compartment paired with 0.5 g/kg ethanol (but not 1.0 g/kg).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat

Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the N...

متن کامل

5-HT2A Serotonin Receptor Density in Adult Male Rats’ Hippocampus after Morphine-based Conditioned Place Preference

Introduction: A close interaction exists between the brain opioid and serotonin (5-HT) neurotransmitter systems. Brain neurotransmitter 5-HT plays an important role in the regulation of reward-related processing. However, a few studies have investigated the potential role of 5-HT2A receptors in this behavior. Therefore, the aim of the present study was to assess the influence of...

متن کامل

Experimental anxiety and the reinforcing effects of ethanol in rats.

In order to examine the relationship between anxiety and reinforcing effects of alcohol, drug-naive male Wistar rats weighing 250-300 g were classified as "anxious" and "non-anxious" in the elevated plusmaze test. A conditioned place preference test was then used to investigate the reinforcing effects of ethanol (EtOH) on these animals. On 2 alternate days, groups of "anxious", "non-anxious" an...

متن کامل

Ethanol induces second-order aversive conditioning in adolescent and adult rats.

Alcohol abuse and dependence are considered public health problems, with an etiological onset often occurring during late childhood and adolescence, and understanding age-related differences in ethanol sensitivity is important. Low to moderate ethanol doses (0.5 and 2.0 g/kg, intragastrically [i.g.]) induce single-trial, appetitive second-order place conditioning (SOC) in adolescent, but not ad...

متن کامل

A comparative study on the effect of L-arginine and morphine in induction of conditioned place preference in rat

It has been shown that L-arginine like the abused drugs could release dopamine from meso-cortico-limbic system. The purpose of the present study was to compare the effect of L-arginine with morphine as a standard abuse drug in the induction of conditioned place preference (CPP) in rat. For this purpose, male Wistar rats (250-300 g) were used in the experiments. Five days after surgical cannulat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Alcohol and alcoholism

دوره 31 6  شماره 

صفحات  -

تاریخ انتشار 1996